The venue’s website said it was closing over issues with the building.
“It is with great regret that we have to announce the permanent closure of the Cockpit.
“After 20 great years as an integral pillar of the Leeds music scene we have decided that it is no longer viable to deliver you the level of service you deserve with the building in it’s current condition.
“We would like to take this opportunity to thank every one of you who came to watch your favourite bands, danced, stage dived, crowd surfed, found your life partner and gave the Cockpit its reputation as one of the best live music venues in the UK.”
It added: “All forthcoming live events will be moved to alternative venues and all original tickets will remain valid.”
The popular venue under the Dark Arches has played host to some of the biggest names in the industry during its two-decade run, including The White Stripes, Amy Winehouse, Arctic Monkeys, Queens of the Stoneage, Flaming Lips, The Libertines, Feeder, Mumford & Sons, Vampire Weekend, The Killers, Fall Out Boy, Bloc Party, Coldplay and The Kaiser Chiefs.
Meanwhile, Futuresound, which runs The Cockpit, have announced their sister company Slam Dunk will open a new live music venue aimed at rock, pop punk and metal fans.
The Key Club will be located on Merrion Street in the city centre and is expected to open on Saturday, September 20.
Both Slam Dunk and the Garage club nights will move from The Cockpit to The Key Club and will take place every week.